4. Genetics
4.1. Chromosomes genes, alleles and mutations
Activity 1: "key to successfully understanding genetics" vocabulary Flashcard (individual - graded)
Activity 2: Outline of Sickle cell anemia - use scale increase as a guideline (base -> codon -> aa -> protein ...) (pairs - class)
Sickle cell anemia: http://www.youtube.com/watch?v=9UpwV1tdxcs
4.2. Meiosis
Activity 3: Karyotyping interactive simulation: http://www.biology.arizona.edu/human_bio/activities/Karyotyping/karyotyping.htm
meiosis video:http://www.youtube.com/watch?v=D1_-mQS_FZ0
independent assortment of alleles: http://www.youtube.com/watch?v=QqGNpTUV1r4&feature=results_main&playnext=1&list=PL12B1DA74937B74C2
4.3. Theoretical genetics
Activity 4: predicting ratios of monohybrid crosses - example studied: blood groups
Activity 5: predicting genotypes using pedigree charts - example studied: hemophilia
Mendelian genetics: http://www.ndsu.edu/pubweb/~mcclean/plsc431/mendel/mendel1.htm
HL - Chapter 10. Genetics
Activity 6: Investigating effect of linkage group on Dihybrid inheritance, using a simulation program - The virtual flies lab.
- Go to http://www.sciencecourseware.org/vcise/ and click on the Drosophila frame (as shown during class), register with the class code 5024842.- Follow instruction and collect data (results of mating).- Use the collected data to explain how linkage groups and crossing-over influence the results of the crossings (compared to expected Mendel’s ratios)Internal assessment -DCP - CE
Note: The data you collect appears in a table. It gives you the phenotypes of the offsprings of your crossings. These are meant to be real crossings, what you need to do next is to calculate ratios or % and then decide if your results match Mendel's ratios or are not matching them, therefore being maybe the result of a linked genes crossing, possibly with very few recombinants, as shown in the textbook. Be careful: Are crossing pure breeds? Are checking F1's or F2's? Please check your texbook to see to which generations and which kind of crossing to apply the Mendeleian ratio's to.
4.4. Genetic Engineering and Biotechnologies
Activity 7: Mind mapping genetic engineering processes and applications to replace techniques in their context of use.
PCR --> http://www.youtube.com/watch?v=2KoLnIwoZKU
DNA fingerprinting / profiling --> http://www.youtube.com/watch?v=ZEidsjaLSGg&feature=related
Uses of database generated by the human genome project --> http://www.youtube.com/watch?v=dZ0cPadsm2g
Craig Venter latest work (2011-2012): http://www.youtube.com/watch?v=SwubQLJRisU
and http://integral-options.blogspot.com/2011/09/tedxnasasilconvalley-craig-venter.html
ethic (TOK) : http://blogs.telegraph.co.uk/culture/tomchivers/100008206/craig-venters-synthetic-life-is-it-really-playing-god/
Activity 1: "key to successfully understanding genetics" vocabulary Flashcard (individual - graded)
Activity 2: Outline of Sickle cell anemia - use scale increase as a guideline (base -> codon -> aa -> protein ...) (pairs - class)
Sickle cell anemia: http://www.youtube.com/watch?v=9UpwV1tdxcs
4.2. Meiosis
Activity 3: Karyotyping interactive simulation: http://www.biology.arizona.edu/human_bio/activities/Karyotyping/karyotyping.htm
meiosis video:http://www.youtube.com/watch?v=D1_-mQS_FZ0
independent assortment of alleles: http://www.youtube.com/watch?v=QqGNpTUV1r4&feature=results_main&playnext=1&list=PL12B1DA74937B74C2
4.3. Theoretical genetics
Activity 4: predicting ratios of monohybrid crosses - example studied: blood groups
Activity 5: predicting genotypes using pedigree charts - example studied: hemophilia
Mendelian genetics: http://www.ndsu.edu/pubweb/~mcclean/plsc431/mendel/mendel1.htm
HL - Chapter 10. Genetics
Activity 6: Investigating effect of linkage group on Dihybrid inheritance, using a simulation program - The virtual flies lab.
- Go to http://www.sciencecourseware.org/vcise/ and click on the Drosophila frame (as shown during class), register with the class code 5024842.- Follow instruction and collect data (results of mating).- Use the collected data to explain how linkage groups and crossing-over influence the results of the crossings (compared to expected Mendel’s ratios)Internal assessment -DCP - CE
Note: The data you collect appears in a table. It gives you the phenotypes of the offsprings of your crossings. These are meant to be real crossings, what you need to do next is to calculate ratios or % and then decide if your results match Mendel's ratios or are not matching them, therefore being maybe the result of a linked genes crossing, possibly with very few recombinants, as shown in the textbook. Be careful: Are crossing pure breeds? Are checking F1's or F2's? Please check your texbook to see to which generations and which kind of crossing to apply the Mendeleian ratio's to.
4.4. Genetic Engineering and Biotechnologies
Activity 7: Mind mapping genetic engineering processes and applications to replace techniques in their context of use.
PCR --> http://www.youtube.com/watch?v=2KoLnIwoZKU
DNA fingerprinting / profiling --> http://www.youtube.com/watch?v=ZEidsjaLSGg&feature=related
Uses of database generated by the human genome project --> http://www.youtube.com/watch?v=dZ0cPadsm2g
Craig Venter latest work (2011-2012): http://www.youtube.com/watch?v=SwubQLJRisU
and http://integral-options.blogspot.com/2011/09/tedxnasasilconvalley-craig-venter.html
ethic (TOK) : http://blogs.telegraph.co.uk/culture/tomchivers/100008206/craig-venters-synthetic-life-is-it-really-playing-god/